Introduction: Dentin exposure during tooth preparation is a factor that influences adhesion, the long-term survival of adhesive restorations, and pulp vitality. Immediate Dentin Sealing (IDS) protocols and selective surface disinfection redefine the management of the dentin surface.

Aim: This manuscript aims to synthesize recent data from the literature on dentin surface disinfection, adhesive system compatibility, and IDS efficiency related to the micromechanical and biological stability of the dentin–adhesive interface, achieving adequate and long-lasting adhesion for restorations. According to the literature data, IDS significantly enhances bond strength and contributes to the reduction of postoperative sensitivity, minimizing microbial infiltration. The most commonly used and efficient disinfectants, CHX and EDTA, are compatible with IDS procedures. Promising bioactive adhesives incorporating antimicrobial and remineralizing agents have been tested, showing positive clinical outcomes and offering new alternatives.
Conclusion: Selective dentin disinfection combined with adequate IDS represents a modern approach in adhesive prosthodontics. Biofunctional adhesive systems, capable of sealing and protecting the dentin surface, offer new perspectives for long-term restorative success and pulpal preservation.

DOI: https://doi.org/10.62838/ASMJ.2025.2.01