The hematogenous marrow tolerance when being in direct contact with the titanium implant

Mihai Pantor 1, Cristian Adrian Rațiu 1, Gabriela Ciavoi 1, Ioana Adela Rațiu 1, Laura Maghiar 1, Adrian Marius Maghiar 1
1 University of Oradea, Faculty of Medicine and Pharmacy, Oradea, Romania

Introduction: The titanium implant represents a foreign body for the organism in which it is inserted, and it will never be accepted as an intrinsic structure. However, research has shown that it is very well supported both by soft and hard tissues, including here the limitrophe implant tissues. Aim of the study: The aim of this study was to test the tolerability towards the titanium implant inserted in direct contact with the hematogenous marrow. Material and methods: Titanium implants with the length of 10 mm and the diameter of 2 mm were inserted in the diaphysis of the femora bone of 10 male rabbits with the age of 10 months. At these particular dimensions, the implant exceeded the depth of the bone wall with more than half its length, taking direct contact with the hematogenous marrow from the marrow channel. Results: Seven days after the implants insertion, the histologic examination revealed the fact that the hematogenous marrow had a very good lenience towards the titanium implant, meaning that it did not lead to any immunological rejection reactions, nor to pathological processes or the tendency of proliferation of unwanted tissues like conjunctive fibrous tissue. In these conditions, the pre-implantation reparatory processes fully benefited of the hematogenous marrow support, which, not being altered in any way, offered cells and stimulant factors, of the same intensity, throughout the entire experimental period. Conclusions: The high tolerance of the hematogenous marrow to the titanium implant assures special conditions for the peri-implantation reparatory processes which take place at a speed that cannot be competed against by other stimulant modalities. This stimulant modality of reparatory processes cannot be applied in all situations, but only when working on healthy bones that contain hematogenous marrow, therefore the practical applicability relates especially to the dental interventions of implant prosthesis.